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An interdisciplinary study led by researchers at the University of South Florida and Indiana University has uncovered significant findings on the long-term effects of one of the most common forms of chemotherapy on cancer survivors.

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This study revealed significant long-term hearing loss in cancer patients treated with cisplatin, a platinum-based chemotherapy agent. Published in the JAMA Oncology journal, the research tracked patients over an average of 14 years, finding that 78 percent experience severe listening difficulties that diminish their quality of life.

Widely used in the treatment of a variety of cancers, cisplatin causes hearing loss by becoming trapped in the ear, leading to inflammation and sensory cell destruction. The study found that higher doses of the drug exacerbate hearing loss. Other serious side effects of cisplatin can include nausea, vomiting, blood in the urine or stools, difficulty in breathing, dizziness, loss of appetite, loss of balance, painful or difficult urination, unusual bleeding or bruising, and weakness in the arms, hands, legs, or feet.

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