This study found that a combination of two natural compounds – nicotinamide (vitamin B3) and epigallocatechin gallate (EGCG), a green tea antioxidant – can rejuvenate aging brain cells and help them clear harmful proteins linked to Alzheimer’s disease. Published in the GeroScience journal, the research shows that these compounds restored levels of guanosine triphosphate (GTP), a vital energy molecule, in brain cells, reversing age-related deficits and boosting the cells’ ability to remove toxic amyloid protein aggregates.
The researchers discovered that aging reduces free GTP levels – especially in the mitochondria, the ‘powerhouses’ of cells – impairing autophagy, the brain cells’ natural cleanup process. Using neurons from aged Alzheimer’s model mice, they found that a 24-hour treatment with nicotinamide and EGCG restored GTP levels to those of younger cells. This improvement enhanced energy metabolism, reactivated key cellular transport proteins, cleared amyloid beta deposits, and reduced oxidative stress, all of which are crucial for maintaining healthy brain function.
To read about research showing that supplements of B vitamins and high levels of omega-3 fatty acids can stop the development of Alzheimer’s disease, see this article on our website.
To check out Dr. Rath’s Cellular Health recommendations for optimum cognitive performance, see this page on our website.
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August 14, 2025Study Finds Vitamin B3 and Green Tea Compound Help Aging Brain Cells Clean Up
News
Researchers at the University of California, Irvine, in the United States have identified a promising nonpharmaceutical treatment that rejuvenates aging brain cells and clears away the buildup of harmful proteins associated with Alzheimer’s disease.
[Source: medicalxpress.com]
[Image source: Adobe Stock]
Comment
This study found that a combination of two natural compounds – nicotinamide (vitamin B3) and epigallocatechin gallate (EGCG), a green tea antioxidant – can rejuvenate aging brain cells and help them clear harmful proteins linked to Alzheimer’s disease. Published in the GeroScience journal, the research shows that these compounds restored levels of guanosine triphosphate (GTP), a vital energy molecule, in brain cells, reversing age-related deficits and boosting the cells’ ability to remove toxic amyloid protein aggregates.
The researchers discovered that aging reduces free GTP levels – especially in the mitochondria, the ‘powerhouses’ of cells – impairing autophagy, the brain cells’ natural cleanup process. Using neurons from aged Alzheimer’s model mice, they found that a 24-hour treatment with nicotinamide and EGCG restored GTP levels to those of younger cells. This improvement enhanced energy metabolism, reactivated key cellular transport proteins, cleared amyloid beta deposits, and reduced oxidative stress, all of which are crucial for maintaining healthy brain function.
To read about research showing that supplements of B vitamins and high levels of omega-3 fatty acids can stop the development of Alzheimer’s disease, see this article on our website.
To check out Dr. Rath’s Cellular Health recommendations for optimum cognitive performance, see this page on our website.
Dr. Rath Health Foundation
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