Fatty liver disease – also known as metabolic dysfunction-associated steatotic liver disease (MASLD) or non-alcoholic fatty liver disease (NAFLD) – is rapidly increasing worldwide, driven largely by poor diet, obesity, and sedentary lifestyles. Closely linked to metabolic conditions such as diabetes and high cholesterol, the condition occurs when excess fat builds up in the liver. There are no widely available drug treatments, leaving lifestyle changes as the primary intervention.
In this study, researchers from the Ulsan National Institute of Science and Technology in South Korea identified a small molecule, microRNA-93 (miR-93), as a major contributor to fatty liver development. Elevated levels of miR-93 block a protective gene known as SIRT1, which normally helps break down fat, reduce inflammation, and maintain liver health. When SIRT1 is suppressed, fat accumulates and liver damage can follow. In testing over 150 compounds, the researchers found that vitamin B3 was the most effective at lowering miR-93 levels, thereby restoring SIRT1 activity and interrupting this harmful process.
To learn how vitamin B12 and folate can also potentially treat advanced NAFLD, see this news story on our website.
The BodyXQ Interactive Health Education Project
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April 3, 2026Study Suggests Vitamin B3 Can Reduce Fatty Liver Risk
News
A new study suggests that vitamin B3 may help reduce liver fat and improve function by targeting a key molecular trigger behind fatty liver disease, offering a simple and affordable treatment possibility.
[Source: newindianexpress.com]
[Image source: Freepik.com]
Comment
Fatty liver disease – also known as metabolic dysfunction-associated steatotic liver disease (MASLD) or non-alcoholic fatty liver disease (NAFLD) – is rapidly increasing worldwide, driven largely by poor diet, obesity, and sedentary lifestyles. Closely linked to metabolic conditions such as diabetes and high cholesterol, the condition occurs when excess fat builds up in the liver. There are no widely available drug treatments, leaving lifestyle changes as the primary intervention.
In this study, researchers from the Ulsan National Institute of Science and Technology in South Korea identified a small molecule, microRNA-93 (miR-93), as a major contributor to fatty liver development. Elevated levels of miR-93 block a protective gene known as SIRT1, which normally helps break down fat, reduce inflammation, and maintain liver health. When SIRT1 is suppressed, fat accumulates and liver damage can follow. In testing over 150 compounds, the researchers found that vitamin B3 was the most effective at lowering miR-93 levels, thereby restoring SIRT1 activity and interrupting this harmful process.
To learn how vitamin B12 and folate can also potentially treat advanced NAFLD, see this news story on our website.
Dr. Rath Health Foundation
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