In this study, published in the journal PLOS One, researchers analyzed MRI brain scans alongside blood samples and found that lower vitamin C levels were linked to reduced gray matter volume and weaker connectivity within the brain’s default mode network, a group of connected brain regions involved in thinking about ourselves, remembering the past, imagining the future, and reflecting on our experiences.
The study also took into account other factors that could influence brain health, including age, physical activity, smoking history, drinking history, and education. Even after adjusting for these variables, the association between higher vitamin C levels and better brain structure remained. The findings add to growing evidence suggesting that maintaining adequate vitamin C status may help support healthy brain aging.
To read about research supporting vitamin C supplementation for the prevention and treatment of Alzheimer’s disease, see this article on our website.
To check out Dr. Rath’s Cellular Health recommendations for optimum cognitive performance, see this page on our website.
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August 7, 2026Vitamin C Levels in Blood Plasma Linked with Brain Connectivity and Volume in Older Adults
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A study of 2,044 older Japanese adults found that those with lower vitamin C levels in their blood plasma tended to have a lower volume of gray matter in their brains, as well as lower connectivity among a collection of brain regions known as the default mode network.
[Source: medicalxpress.com]
[Image source: magnific.com]
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In this study, published in the journal PLOS One, researchers analyzed MRI brain scans alongside blood samples and found that lower vitamin C levels were linked to reduced gray matter volume and weaker connectivity within the brain’s default mode network, a group of connected brain regions involved in thinking about ourselves, remembering the past, imagining the future, and reflecting on our experiences.
The study also took into account other factors that could influence brain health, including age, physical activity, smoking history, drinking history, and education. Even after adjusting for these variables, the association between higher vitamin C levels and better brain structure remained. The findings add to growing evidence suggesting that maintaining adequate vitamin C status may help support healthy brain aging.
To read about research supporting vitamin C supplementation for the prevention and treatment of Alzheimer’s disease, see this article on our website.
To check out Dr. Rath’s Cellular Health recommendations for optimum cognitive performance, see this page on our website.
Dr. Rath Health Foundation
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