Workers’ Pesticide Exposure Linked to 60-70 Percent Heightened Motor Neuron Disease Risk

This new review of existing research found that people who are exposed to pesticides at work may face a significantly higher risk of developing amyotrophic lateral sclerosis (ALS), the most common form of motor neuron disease. The analysis revealed that any workplace exposure to pesticides was associated with a 60 percent higher risk of ALS, while exposure to herbicides was linked to a 70 percent higher risk. In studies involving men, those exposed to pesticides were twice as likely to develop ALS as those who were not exposed.

The researchers combined evidence from studies published between 1990 and 2025, including research involving more than 1,700 people with ALS. The findings suggested that the greater the exposure, the greater the risk. People exposed to high levels of pesticides had almost three times the risk of ALS, while those with lower levels of exposure had about twice the risk. Exposure to insecticides and fungicides was also associated with an increased risk. Interestingly, however, the analysis did not find a clear increase in risk among women who had been exposed to pesticides.

The results add to growing concerns about the long-term effects of these toxic chemicals on the nervous system. The researchers say that this should encourage the implementation of interventions aimed at reducing occupational exposure.

To read about research linking omega-3 fatty acids with slower progression of ALS, see this news story on our website.