In patients with chronic obstructive pulmonary disease (COPD) and chronic respiratory failure on long-term oxygen therapy, adding oral L-arginine plus liposomal vitamin C to a structured pulmonary rehabilitation program was associated with a greater reduction in fatigue than placebo.

A two-year randomized controlled trial has found that daily supplementation with vitamin K2 and vitamin D3 was associated with a 21 percent reduction in the progression of coronary artery calcification compared with placebo.

A new analysis estimates that targeted supplementation with omega-3 fatty acids EPA and DHA, phytosterols, and beta-glucans could generate substantial societal cost savings by improving heart health among specific populations.