Higher Intakes of Omega-3 Fatty Acids Associated With Lower Risk of Death

Omega-3 fatty acids are increasingly being shown to provide significant health benefits, particularly in relation to cardiovascular disease. Acknowledging this, a new meta-analysis authored by researchers from the United States examines the connection between one specific type of omega-3 – docosahexaenoic acid (DHA) – and mortality rates. Studying data on 117,702 people from the UK, the researchers analyze plasma DHA levels and track mortality over a period of 12.7 years. Published in the Mayo Clinic Proceedings journal, the findings demonstrate a clear correlation between higher circulating levels of DHA and a lower risk of all-cause mortality.

The primary data used for the analysis was taken from the UK Biobank, a resource containing in-depth genetic, lifestyle, and health information on around half a million people from England, Scotland, and Wales. For a secondary analysis, the researchers merged the UK Biobank findings with those from a recent FORCE (Fatty Acid and Outcome Research Consortium) meta-analysis that included 17 studies and 42,702 individuals. Combined with the Biobank data on 117,702 people, this produced an expanded sample population of 160,404 individuals who were followed for an average of 14 years.

For people with the highest circulating levels of DHA, the UK Biobank data revealed a 21 percent lower risk of all-cause mortality. About half of those with the highest levels were taking supplemental omega-3 fatty acids. Merging the Biobank findings with those from the FORCE meta-analysis and adjusting for relevant risk factors gave a 17 percent lower risk of all-cause mortality, a 21 percent lower risk for cardiovascular disease mortality, a 17 percent lower risk for cancer mortality, and a 15 percent lower risk for other causes of mortality.

The researchers suggest that, for the average American, a combined daily intake of approximately 1,000 mg of DHA and EPA (eicosapentaenoic acid, another omega-3 fatty acid) would be required to achieve the levels shown to be cardioprotective. They further estimate that individuals with the lowest omega-3 intakes would need 1,600 mg per day.

Said to be one of the largest ever to examine the relationship between DHA status and mortality, the study concludes that higher levels of this fatty acid are associated with significant risk reductions in all-cause mortality, as well as reduced risks for deaths due to cardiovascular disease, cancer, and other causes. The researchers say their findings strengthen the hypothesis that DHA may support cardiovascular health and lifespan.

Taking advantage of nutrient synergy

For optimum reductions in mortality risk, paying attention to omega-3 fatty acids alone is not enough. Vitamin D levels are also important, for example, having been shown to predict future health problems and risk of death. Acceptance that daily doses of vitamin D3 reduce mortality from cancer is gradually becoming mainstream. Researchers in the United States have shown that vitamin C intake is inversely related to mortality risk.

As opposed to focusing on individual nutrients, the most effective approach is to ensure a balanced intake of synergistic nutrients that are carefully chosen so as to maximize their biological impact. Dr. Rath’s Cellular Health Recommendations set the benchmark in this respect, comprising a cutting-edge selection of specific vitamins, minerals, amino acids, and trace elements.

The result of decades of scientific research, Dr. Rath’s approach to daily nutrient supplementation is designed for everyone – young and old, healthy persons and patients alike — with the goal of optimizing cardiovascular health, preventing chronic diseases, and reducing mortality risk. Based on the findings of the latest Mayo Clinic Proceedings study, incorporating omega-3 fatty acids into such a regimen may be one of the best things you can do towards enhancing and protecting your health.