Responsibility for a healthy world
November 15, 2023
Vitamin B12 Insufficiency Linked With Higher Risk Of Gestational Diabetes
November 16, 2023

Omega-3 May Be An “Effective Add-On Therapeutic” For Depression


A new umbrella review of meta-analyses investigating the effect of long-chain omega-3 supplementation on depressive symptoms concludes the majority of studies observe a significant effect, particularly in those with major depressive disorder.


A meta-analysis published in 2016 looked at 13 studies involving 1,233 participants and similarly found that supplementation with omega-3 fatty acids can help reduce symptoms of major depressive disorder. A study published in 2018 added still further support to the use of omega-3 fatty acids for controlling depression, finding that higher levels of these nutrients are linked to less depression in heart failure patients.

Other research has found evidence linking a deficiency of B vitamins with depression. A scientific review published in 2017 noted that low levels of B vitamins are common in depression and that supplementation with these nutrients has been shown to improve outcomes.

Similarly, a clinical trial published in 2017 showed that magnesium supplements are effective in the treatment of mild-to-moderate depression. Finding that daily supplementation with magnesium leads to a significant decrease in depression and anxiety symptoms, and that it works quickly and is well tolerated, the study concluded that magnesium may be a safe over-the-counter alternative to antidepressant drugs.

A study published in 2014 provided clinical evidence that curcumin, the most abundant natural phenol present in turmeric, may be used as a safe and effective treatment for treating patients with major depressive disorder. Other research has found that correcting vitamin D deficiency in depressed patients can improve their condition. In a study published in 2013, Iranian researchers found that, in a randomized clinical trial, a single 300,000 IU vitamin D injection was safe and effective in improving depression in patients who were vitamin D deficient.

To read how vitamin-rich Mediterranean diets have been shown to help prevent depression, see this article on our website.